香港2018买马最准资料
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Apixaban intermeidate cas 503615-03-0

Product Description

Chemical Name: 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Molecular Formula: C15H17N3O4
Formula Weight: 303.31318
CAS No.: 503615-03-0

503615-03-0

An alternate approach to Apixaban was described. The synthesis features a novel and cost-effective synthetic strategy to construct a key N-phenylvalerolactam intermediate 4 from 4-nitroaniline. In addition, the modified synthetic route avoids the use of expensive reagents and significantly improves reaction yields. As demonstrated practically, apixaban was successfully synthesized in overall good yield (35%).

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香港2018买马最准资料